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The following additional adverse experiences have been observed in women taking progestins in generalbreakthrough bleedingspottingchange in menstrual flowamenorrheachanges in weightincrease or decreasechanges in the cervical squamo-columnar junction and cervical secretionscholestatic jaundiceanaphylactoid reactions and anaphylaxisrashallergicwith and without pruritusmelasma or chloasmapyrexiaand insomnia.
No formal studies have evaluated the effect of hepatic disease on the disposition of progesteroneHoweversince progesterone is metabolized by the liveruse in patients with severe liver dysfunction or disease is contraindicatedsee CONTRAINDICATIONSIf treatment with progesterone is indicated in patients with mild to moderate hepatic dysfunctionthese patients should be monitored carefully.
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