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Diphenhydramine adds to exaggerates the sedating effects of alcohol and other drugs than can cause sedation such as the benzodiazepine class of anti-anxiety for example, diazepam valium , lorazepam ativan , clonazepam klonopin , alprazolam xanax , the narcotic class of pain medications and its derivatives for example, oxycodone and acetaminophen percocet , and hydrocodone and acetaminophen vicodin , guaifenesin with hydromorphone dilaudid , codeine, propoxyphene darvon , the tricyclic class of antidepressants for example, amitriptyline elavil, endep , imipramine tofranil , desipramine norpramin , and certain antihypertensive medications for example, clonidine catapres , propranolol inderal .
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